A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer
Status
RECRUITING
Phase
PHASE2
Age
≥ 18 Years
Enrollments
102Conditions
Prostate Cancer, Prostate Adenocarcinoma, Localized Prostate CarcinomaSummary
The purpose of this study is to find out the effects of exercise therapy on indicators of prostate cancer in people with low-risk prostate cancer who are on active surveillance. The exercise therapy in this study will be regular home-based walking sessions on a treadmill, and that therapy will be assigned by an exercise physiologist (a medical professional who studies how exercise affects the human body). Some participants in this study will have the assigned exercise therapy, and some participants will participate in their usual exercise routines. Researchers will compare how the assigned exercise therapy and the usual exercise routines affect indicators of prostate cancer in participants. This study will not provide treatment for prostate cancer.
Locations
7 locations Found with status Recruiting
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Status
- RECRUITING
Contact Person
- Lee Jones, PhD
- 646-888-8103
Principal Investigator
- Lee Jones, PhD
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18
* Men with histologically confirmed localized prostate cancer undergoing active surveillance.
* Inactive, defined as not meeting the national exercise guidelines for cancer patients (<150 minutes/week of moderate or vigorous exercise)43 as assessed by remote activity and heart rate tracking for a 7-day period prior to study entry (general physical activity screening assessment via smart watch).
* Screening clearance by an MSK Exercise Physiologist (i.e., review of ECG and PAR-Q)
* BMI <40 kg/m^2
Exclusion Criteria:
* Enrollment in any other program that may alter the impact of exercise on tumor outcomes (e.g., weight loss program)
* Any neoadjuvant anticancer treatment of any kind for prostate cancer in the last 5 years
* Any history of systemic anticancer therapy in the last 15 years
* Distant metastatic malignancy of any kind
* Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation
Study Plan
Participants Assigned to Exercise Therapy
EXPERIMENTAL
Participants with histologically confirmed localized prostate cancer undergoing active surveillance
BEHAVIORAL:
Exercise TherapyDescription:
The intervention will consist of exercise therapy, individualized, walking delivered following a non-linear (i.e., exercise dose is continually altered and progressed in conjunction with appropriate rest/recovery sessions across the entire intervention period) dosing schedule, up to 5 individual treatment sessions/week to achieve a cumulative total duration of 225 to 300 mins/wk until the participant's next standard of care prostate biopsy (about 6-12 months).
Participants Assigned to Usual Care
NO_INTERVENTION
Participants with histologically confirmed localized prostate cancer undergoing active surveillance
Outcome Measures
Primary Outcome Measures
Change in molecular, radiologic, and pathologic nimbosus hallmarks from baseline to follow-up
Timeline
Last Updated
November 8, 2024Start Date
March 2, 2023Today
February 5, 2025Completion Date ( Estimated )
February 10, 2027
Sponsors of this trial
Lead Sponsor
Memorial Sloan Kettering Cancer Center
RECRUITING 
21 - 64 Years