Collection of Blood in Studying Metabolites in Patients With Prostate Cancer
Status
RECRUITING
Phase
Age
≥ 18 Years
Enrollments
10Conditions
Prostate CarcinomaSummary
This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living cells. Collecting blood in order to study metabolites may help doctors monitor and treat prostate cancer more effectively.
Detailed Description
PRIMARY OBJECTIVES:
I. Develop blood sample collection and preparation procedures for reliable, meaningful metabolomic profiling of peripheral blood mononuclear cells (PBMCs) by liquid chromatography/quadruple-time of flight/mass spectrometry (LC/Q-TOF/MS) that can be implemented in a clinical setting.
II. Optimize data analysis methods and software usage to create a metabolic profile for patients at the time of blood collection.
III. Compare metabolite profiles of isolated PBMCs versus (vs.) other blood fractions (plasma, red blood cells [RBCs], and whole blood).
IV. Identify elements of the PBMC metabolite profile that may correlate to patient disease state.
OUTLINE:
Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
Locations
1 location Found with status Recruiting
Status
- RECRUITING
Contact Person
- Jonathan Katz
- 323-205-5289
Principal Investigator
- Jonathan Katz, Ph.D.
Eligibility Criteria
Inclusion Criteria:
* All subjects will have histologically confirmed prostate cancer
* Provide written consent/authorization to participate in this study
* Have no signs or symptoms of active infection
* Exhibit a willingness to comply with the experimental procedures as outlined in this protocol
Study Plan
Diagnostic (biospecimen collection)
Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
PROCEDURE:
Biospecimen CollectionDescription:
Undergo collection of bloodOTHER:
Laboratory Biomarker AnalysisDescription:
Correlative studies
Outcome Measures
Primary Outcome Measures
Blood sample collection
Timeline
Last Updated
March 18, 2024Start Date
April 2, 2018Today
May 12, 2025Completion Date ( Estimated )
November 14, 2026
Sponsors of this trial
Lead Sponsor
University of Southern CaliforniaCollaborating Sponsors
National Cancer Institute (NCI)
RECRUITING 
≥ 18 Years