Metabolic Impact of Prospective Controlled Mediterranean Type Diets on Prostate Cancer

Clinicaltrials.gov ID: NCT05590624

Status RECRUITING

Phase NA

Age ≥ 18 Years

Enrollments 30

Conditions

Prostate Cancer

Summary

The purpose of this study is to examine the impact of Mediterranean-type diets on the metabolism of men with localized prostate cancer.The optimal diet for men with a suspected diagnosis of Prostate Cancer (PCa) is currently unknown. More specifically, the suggested benefits of low carbohydrate and low fat diets in PCa are not determined.

Detailed Description

Primary Objective

-Evaluate the impact of Mediterranean diets (Med-t-Diets) on non-malignant prostate tissue metabolism

Secondary Objectives

* Evaluate the impact of Med-t-Diets on host metabolism
* Evaluate the impact of Med-t-Diets on systemic biomarkers after consuming Med-t-Diets
* Evaluate the impact of Med-t-Diets on the microbiome and dietary behavior and compliance after consuming Med-t-Diets

Locations

1 location Found with status Recruiting

Status

RECRUITING

Contact Person

Dianna Sendrey, RN, BSN

Principal Investigator

Christopher Weight, MD

Eligibility Criteria

Inclusion Criteria:

* Males ≥18 years old
* High suspicion of prostate cancer (PCa) per urologist's clinical evaluation
* BMI >18.5
* No prior PCa diagnosis or hormonal therapy (-ies)
* Ability to read, write, speak, and understand English
* Ability to provide informed consent
* Candidate for and elects active surveillance (AS) if diagnostic biopsy is positive
* Willingness to consume provided dietary interventions
* Adequate organ and marrow function: White blood cell count (WBC) ≥2,500/mcL, Absolute neutrophil count (ANC) ≥1,500/mcL, Platelets ≥100,000/mcL, Hemoglobin ≥9 g/dL (transfusions permitted), Total bilirubin ≤1.5 x the institutional upper limit of normal (ULN) (for subjects with Gilbert's disease ≤3.0 mg/dL), Aspartate aminotransferase (AST)/Alanine aminotransferase (ALT) ≤2.5 x institutional ULN, Creatinine clearance ≥51 ml/min as defined by Cockcroft-Gault equation

Exclusion Criteria:

* Currently consuming a Mediterranean, lower carbohydrate, ketogenic, vegan, vegetarian, high fiber diet (14g fiber > per 1,000 Calories) and/or any supplements (including herbal), vitamins, minerals, that would interfere with diets being tested in the study as determined by dietitian and/or investigators.
* Previous intolerability to fiber-rich diets
* Colitis, Irritable Bowel Syndrome, or other gastrointestinal condition per clinician discretion
* Unwilling to undergo transperineal PCa biopsies
* Food allergies or other major dietary restrictions
* Receiving active medical treatment for Type I or Type II diabetes mellitus
* Prior antibiotic usage (i.e. within last 30 days) at time of consent
* Recent weight loss (both intentional and unintentional) as defined by 5%+ body weight in the last 30 days
* Undergone any type of weight loss surgery
* Any medical contraindications as determined by investigators
* High risk as defined by PSA≥20 and/or PI-RADS 5 lesion as per clinician evaluation
* History of diabetic ketoacidosis
* Gout
* Patients that are immunosuppressed (transplant history, on immunosuppression, etc.) as per clinician discretion
* Recent (within last 30 days) device implant/joint requiring antibiotics as per clinician determination
* Prior history of prostate biopsy infection
* Uncontrolled hypertension as defined by blood pressure greater than 140/80 (with or without medication)
* Gallbladder removed or plan to remove per clinician evaluation
* Other malignancies actively receiving systemic treatment as per clinician evaluation

Study Plan

Mediterranean-type Diet(s)-Arm 1

EXPERIMENTAL

Diet randomization occurs two weeks prior to the Standard of Care (SOC) diagnostic biopsy. If patient is randomized to Arm 1, they will receive Low Fat (LF) Mediterranean Diet first. The results of the diagnostic biopsy determines how the patient will proceed on the trial. If there is a confirmed Prostate Cancer (PCa) diagnosis AND is a candidate for Active Surveillance (AS) per SOC, then patient will undergo a washout period and cross-over to the Lower Carbohydrate (LC) Mediterranean Diet two weeks prior to the SOC confirmatory biopsy. A long-term follow-up (LTFU) visit will occur 3 months after the second dietary intervention has concluded. If patient does not have PCa or is not placed on AS, then they will only have the first dietary intervention and a LTFU visit 3 months after

OTHER:
Lower-Carbohydrate Med-t-Diet
Description:
Diet will focus on including:nn* Lean protein sourcesn* High-quality fatn* High-quality carbohydrate sources that are rich in fibern* Nuts and seedsnnDiet will focus on limiting:nn* Refined sugarsn* High glycemic carbohydratesn* Seed oils that may cause inflammationnnDiet Composition: 45% fats, 35% carbs, 20% protein
OTHER:
Low-Fat Med-t-Diet
Description:
Diet will focus on including:nn* Lean protein sourcesn* High-quality fatn* High-quality carbohydrate sources that are rich in fibern* Nuts and seedsnnDiet will focus on limiting:nn* Refined sugarsn* High glycemic carbohydratesn* Seed oils that may cause inflammationnnDiet Composition: 70% carbs, 20% protein, 10% fat

Mediterranean-type Diet(s)-Arm 2

EXPERIMENTAL

Diet randomization occurs two weeks prior to the Standard of Care (SOC) diagnostic biopsy. If patient is randomized to Arm 2, they will receive Lower Carbohydrate (LC) Mediterranean Diet first. The results of the diagnostic biopsy determines how the patient will proceed on the trial. If there is a confirmed Prostate Cancer (PCa) diagnosis AND is a candidate for Active Surveillance (AS) per SOC, then patient will undergo a washout period and cross-over to the Low Fat (LF) Mediterranean Diet two weeks prior to the SOC confirmatory biopsy. A long-term follow-up (LTFU) visit will occur 3 months after the second dietary intervention has concluded. If patient does not have PCa or is not placed on AS, then they will only have the first dietary intervention and a LTFU visit 3 months after.

OTHER:
Lower-Carbohydrate Med-t-Diet
Description:
Diet will focus on including:nn* Lean protein sourcesn* High-quality fatn* High-quality carbohydrate sources that are rich in fibern* Nuts and seedsnnDiet will focus on limiting:nn* Refined sugarsn* High glycemic carbohydratesn* Seed oils that may cause inflammationnnDiet Composition: 45% fats, 35% carbs, 20% protein
OTHER:
Low-Fat Med-t-Diet
Description:
Diet will focus on including:nn* Lean protein sourcesn* High-quality fatn* High-quality carbohydrate sources that are rich in fibern* Nuts and seedsnnDiet will focus on limiting:nn* Refined sugarsn* High glycemic carbohydratesn* Seed oils that may cause inflammationnnDiet Composition: 70% carbs, 20% protein, 10% fat

Outcome Measures

Primary Outcome Measures