The Registry of Oncology Outcomes Associated With Testing and Treatment
Status
RECRUITING
Phase
Age
≥ 18 Years
Enrollments
100000Conditions
Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer, Brain Tumor, Glioblastoma, Astrocytoma, Bile Duct Cancer, Cholangiocarcinoma, Bladder Cancer, Bone Cancer, Synovial Sarcoma, Chondrosarcoma, Liposarcoma, Sarcoma, Kaposi, Sarcoma,Soft Tissue, Sarcoma, Osteosarcoma, CNS Cancer, Brain Stem Neoplasms, Breast Cancer, Cervical Cancer, Colorectal Cancer, Rectal Cancer, Colon Cancer, Esophageal Cancer, Esophagus Cancer, Cancer of Colon, Pancreatic Cancer, Cancer of Pancreas, Testis Cancer, Testicular Cancer, Ureter Cancer, Renal Cell Carcinoma, Kidney Cancer, Gestational Trophoblastic Tumor, Head and Neck Neoplasms, Parotid Tumor, Larynx Cancer, Tongue Cancer, Pharynx Cancer, Salivary Gland Cancer, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Acute Lymphoblastic Leukemia, Multiple Myeloma, Non Hodgkin Lymphoma, Carcinoid Tumor, Lung Cancer, Neuroendocrine Tumors, Mesothelioma, Thyroid Cancer, Parathyroid Neoplasms, Adrenal Cancer, Small Bowel Cancer, Stomach Cancer, Liver Cancer, Hepatic Cancer, Melanoma, Skin Cancer, Unknown Primary Tumors, Uterine Cancer, Fallopian Tube Cancer, Ovarian Cancer, Prostate Cancer, Vaginal Cancer, Penile Cancer, Vulvar Cancer, Waldenstrom Macroglobulinemia, Cancer, Advanced, Thymus Cancer, Nasopharyngeal Carcinoma, Multiple Endocrine Neoplasia, Pheochromocytoma, Small Cell Carcinoma, Pulmonary CarcinomaDrugs
Systemic Treatment (T)Summary
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation. It will also create reusable infrastructure to allow creation or affiliation with many additional RWD/RWE efforts both prospective and retrospective in nature.
Detailed Description
This is a master observational trial (MOT). Anyone who has been diagnosed with advanced cancer is eligible as long as they are a candidate for treatment. Each patient will receive testing and treatment as determined by patient in consultation with physician. ROOT will proceed in two directions: (1) Validation Cohorts. These patients will demonstrate the ability of the MOT to prospectively collect data using the same protocol and related documents, standardized data elements and processes, and accepted scientific endpoints; and (2) Analysis Cohorts. The modular nature of the study allows collection of RWD ranging from diagnosis only to the full treatment course of the of the patient. Patients are grouped to allow focused data collection or a specific analysis. Analysis cohorts can be created from patients already enrolled in ROOT or be defined prospectively. Because of the ongoing advancements of molecular based oncology, this trial allows a detailed focus on molecular testing as part of any cohort.
Data is reported by the group that is most qualified to provide this information and is proved, at point of care, using standardized data elements and processes. Physicians will report diagnosis, molecular characteristics, staging, disease burden, significant comorbidities, treatment response, and medical decision making. Molecular testing (reports and details) will be requested from testing laboratories. Any diagnostic films will be received digitally from the location the study was performed. Research staff assist in data entry and providing physicians needed data as part of the regular workflow to allow point-of-care reporting.
The Validation Cohorts and Analysis Cohorts may run sequentially or in parallel with each other.
Locations
2 locations Found with status Recruiting
Status
- RECRUITING
Contact Person
- Manager of Oncology Services
- 208-356-9559
- [email protected]
Study Chair
- Razelle Kurzrock, MD
Status
- RECRUITING
Contact Person
- Cesar Flores
- 872-222-7830
- [email protected]
Study Chair
- Razelle Kurzrock, MD
Eligibility Criteria
Inclusion Criteria:
* Patient or representative provides written informed consent
* Patient is diagnosed with advanced malignancy
* Patient is willing to be treated for this malignancy according to a plan determine by them and their physician
* patient will be willing to have regular follow up visits as part of their standard of care
Exclusion Criteria:
* patient is not a candidate or does not desire any treatment for their disease
Outcome Measures
Primary Outcome Measures
Best overall response (BOR) - 1st line of therapy
Best overall response (BOR) - 2nd line of therapy
Best overall response (BOR) - 3rd line of therapy
Best overall response (BOR) - 4th line of therapy
Best overall response (BOR) - 5th line of therapy
Progression-free survival (PFS) - 1st line of therapy
Progression-free survival (PFS) - 2nd line of therapy
Progression-free survival (PFS) - 3rd line of therapy
Progression-free survival (PFS) - 4th line of therapy
Progression-free survival (PFS) - 5th line of therapy
Secondary Outcome Measures
Overall survival (OS)
Timeline
Last Updated
November 21, 2023Start Date
July 22, 2019Today
January 23, 2025Completion Date ( Estimated )
October 1, 2031
Sponsors of this trial
Lead Sponsor
Taproot Health
RECRUITING 
21 - 64 Years