Using FAPI PET/MRI to Evaluate Prostate Cancer
Conditions
Prostate Cancer Metastatic Disease, Prostate CancersSummary
The goal of this clinical trial is to gain more information about how FAPI (fibroblast activation protein inhibitor) binds to certain type of cells in the tumor tissue. The main question it aims to answer is how this information can be used to better diagnose and track prostate cancer.Participants will undergo two PET/MRI scans during two research visits, each of which may last up to 2.5 hours.
Locations
1 location Found with status Recruiting
Status
- RECRUITING
Contact Person
- Suzanne Hanson
- 608-282-8349
- [email protected]
Principal Investigator
- Ali Pirasteh, MD
Eligibility Criteria
Inclusion Criteria:
* Age 18 years or older
* Able and willing to provide informed consent
* Known diagnosis of prostate cancer with established or suspected non-osseous, non-nodal metastases
* Scheduled for standard-of-care PSMA PET
* Scheduled for SOC biopsy of an established or suspected non-osseous, non-nodal metastases
* Willing and able to undergo PET/MRI as part of this research
Exclusion Criteria:
* Unable or unwilling to provide informed consent
* Contraindication(s) to or inability to undergo PET/MRI
* Participants for whom PET/MRI will delay timely delivery of treatment
* Participants requiring intravenous (IV) conscious sedation for imaging care; those requiring mild, oral anxiolytics for the clinical MRI will be allowed to participate as long as the following criteria are met:
* Have their own prescription for the medication
* The informed consent process is conducted prior to the self-administration of this medication
* Come to the research visit with a driver
Study Plan
Fibroblast activation protein inhibitor (FAPI)
EXPERIMENTAL
FAPI radiotracer will be used during PET
RADIATION:
FAPIDescription:
5 +/- 2 mCi of Ga-FAPI-46PROCEDURE:
Positron Emission Tomography (PET)Description:
Undergo PET scanPROCEDURE:
Magnetic Resonance ImagingDescription:
Undergo MRI scan
Outcome Measures
Primary Outcome Measures
Performance of FAPI for lesion detection
Lesion FAPI uptake on PET
Total FAPI-positive tumor volume change
Timeline
Last Updated
November 21, 2024Start Date
November 5, 2024Today
January 23, 2025Completion Date ( Estimated )
October 1, 2026
Sponsors of this trial
Lead Sponsor
University of Wisconsin, Madison